Article
DNMT3A -448A>G polymorphism and cancer risk: a meta-analysis.
Genetics and molecular research : GMR - 17 Apr 2015
Liu C H, Tao T, Jiang L, Xu B, Zhang L, Lu K, Zhang X W, Chen S Q, Liu D C, Chen M
Abstract excerpt
Cancer is a major public health problem worldwide that involves complex processes and factors. For instance, methylation is important in tumorigenesis. DNA (cytosine-5)-methyltransferase 3A (DNMT3A) is the main de novo methyltransferase implicated in this process. In DNMT3A, the -448A>G polymorphism is associated with cancer; however, the results of various studies have been conflicting. To clarify the role of...
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