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Article

Engineering neuronal nicotinic acetylcholine receptors with functional sensitivity to alpha-bungarotoxin: a novel alpha3-knock-in mouse.

The European journal of neuroscience - 3 Dec 2009

Caffery Philip M, Krishnaswamy Arjun, Sanders Tanya, Liu Jing, Hartlaub Hilary, Klysik Jan, Cooper Ellis, Hawrot Edward

Abstract excerpt

We report here the construction of a novel knock-in mouse expressing chimeric alpha3 nicotinic acetylcholine receptor (nAChR) subunits with pharmacological sensitivity to alpha-bungarotoxin (alphaBTX). Sensitivity was generated by substituting five amino acids in the loop C (beta9-beta10) region of the mouse alpha3 subunit with the corresponding residues from the alpha1 subunit of the muscle type receptor from...

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Identifiers

PMID: 20128845
DOI: 10.1111/j.1460-9568.2009.07016.x
PMCID: PMC2818262

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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