Integrative genomic approaches identify IKBKE as a breast cancer oncogene.

doi:10.1016/j.cell.2007.03.052

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Article

Integrative genomic approaches identify IKBKE as a breast cancer oncogene.

Cell - 15 Jun 2007

Boehm Jesse S, Zhao Jean J, Yao Jun, Kim So Young, Firestein Ron, Dunn Ian F, Sjostrom Sarah K, Garraway Levi A, Weremowicz Stanislawa, Richardson Andrea L, Greulich Heidi, Stewart Carly J, Mulvey Laura A, Shen Rhine R, Ambrogio Lauren, Hirozane-Kishikawa Tomoko, Hill David E, Vidal Marc, Meyerson Matthew, Grenier Jennifer K, Hinkle Greg, Root David E, Roberts Thomas M, Lander Eric S, Polyak Kornelia, Hahn William C

Abstract excerpt

The karyotypic chaos exhibited by human epithelial cancers complicates efforts to identify mutations critical for malignant transformation. Here we integrate complementary genomic approaches to identify human oncogenes. We show that activation of the ERK and phosphatidylinositol 3-kinase (PI3K) signaling pathways cooperate to transform human cells. Using a library of activated kinases, we identify several kinases...

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Identifiers

PMID: 17574021
DOI: 10.1016/j.cell.2007.03.052

Genes

IKBKE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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