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Article

Disturbance of cardiac gene expression and cardiomyocyte structure predisposes Mecp2-null mice to arrhythmias.

Scientific reports - 15 Jun 2015

Hara Munetsugu, Takahashi Tomoyuki, Mitsumasu Chiaki, Igata Sachiyo, Takano Makoto, Minami Tomoko, Yasukawa Hideo, Okayama Satoko, Nakamura Keiichiro, Okabe Yasunori, Tanaka Eiichiro, Takemura Genzou, Kosai Ken-ichiro, Yamashita Yushiro, Matsuishi Toyojiro

Abstract excerpt

Methyl-CpG-binding protein 2 (MeCP2) is an epigenetic regulator of gene expression that is essential for normal brain development. Mutations in MeCP2 lead to disrupted neuronal function and can cause Rett syndrome (RTT), a neurodevelopmental disorder. Previous studies reported cardiac dysfunction, including arrhythmias in both RTT patients and animal models of RTT. In addition, recent studies indicate that MeCP2...

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Identifiers

PMID: 26073556
DOI: 10.1038/srep11204
PMCID: PMC4466896

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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