Article
MGAT5 and disease severity in progressive multiple sclerosis.
Journal of neuroimmunology - 1 Jan 2011
Esposito Federica, Wojcik Jerome, Rodegher Mariaemma, Radaelli Marta, Moiola Lucia, Ghezzi Angelo, Capra Ruggero, Brambilla Paola, Sorosina Melissa, Giacalone Giacomo, Martinelli Vittorio, Comi Giancarlo, Abderrahim Hadi, Martinelli Boneschi Filippo
Abstract excerpt
MGAT5 was demonstrated to be associated to multiple sclerosis (MS) severity. We evaluated its role in progressive MS. We studied 11 SNPs mapping to MGAT5 in an Italian cohort of primary progressive or progressive-relapsing patients. The rs1257169(G) allele is associated with lower disease severity (p-value = 0.02). Adding the age of onset as covariate, another SNP, rs539588, is nominally significant. None of the...
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