Article
Genetic variation near IRF8 is associated with serologic and cytokine profiles in systemic lupus erythematosus and multiple sclerosis.
Genes and immunity - 1 Dec 2013
Chrabot B S, Kariuki S N, Zervou M I, Feng X, Arrington J, Jolly M, Boumpas D T, Reder A T, Goulielmos G N, Niewold T B
Abstract excerpt
Alleles of interferon (IFN) regulatory factor 8 (IRF8) are associated with susceptibility to both systemic lupus erythematosus (SLE) and multiple sclerosis (MS). Although high-type I IFN is thought to be causal in SLE, type I IFN is used as a therapy in MS. We investigated whether IRF8 alleles were associated with type I IFN levels or serologic profiles in SLE and MS. Alleles that have been previously associated...
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