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Article

Drosophila Dok is required for embryonic dorsal closure.

Development (Cambridge, England) - 1 Jan 2006

Biswas Romi, Stein David, Stanley E Richard

Abstract excerpt

Embryonic dorsal closure (DC) in Drosophila is a series of morphogenetic movements involving the bilateral dorsal movement of the epidermis (cell stretching) and dorsal suturing of the leading edge (LE) cells to enclose the viscera. The Syk family tyrosine kinase Shark plays a crucial role in this Jun amino-terminal kinase (JNK)-dependent process, where it acts upstream of JNK in LE cells. Using a yeast...

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Source

Identifiers

PMID: 16339186
DOI: 10.1242/dev.02198

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drosophila Dok is required for embryonic dorsal closure.PMID 16339186Read ↗

The dorsal-open group gene raw is required for restricted DJNK signaling during closure.Semantic proximity Read ↗

Signalling crosstalk at the leading edge controls tissue closure dynamics in the Drosophila embryo.Semantic proximity Read ↗

JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis.Semantic proximity Read ↗

Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper.Semantic proximity Read ↗

bullwinkle and shark regulate dorsal-appendage morphogenesis in Drosophila oogenesis.Semantic proximity Read ↗

Sec61alpha is required for dorsal closure during Drosophila embryogenesis through its regulation of Dpp signaling.Semantic proximity Read ↗

Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure.Semantic proximity Read ↗

Common and distinct roles of DFos and DJun during Drosophila development.Semantic proximity Read ↗

Downregulation of Jun kinase signaling in the amnioserosa is essential for dorsal closure of the Drosophila embryo.Semantic proximity Read ↗

Cabut, a C2H2 zinc finger transcription factor, is required during Drosophila dorsal closure downstream of JNK signaling.Semantic proximity Read ↗

Leading edge-secreted Dpp cooperates with ACK-dependent signaling from the amnioserosa to regulate myosin levels during dorsal closure.Semantic proximity Read ↗

Dpp signalling orchestrates dorsal closure by regulating cell shape changes both in the amnioserosa and in the epidermis.Semantic proximity Read ↗

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