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Article

JAK/STAT/SOCS-signaling pathway and colon and rectal cancer.

Molecular carcinogenesis - 1 Feb 2013

Slattery Martha L, Lundgreen Abbie, Kadlubar Susan A, Bondurant Kristina L, Wolff Roger K

Abstract excerpt

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway is involved in immune function and cell growth. We evaluated the association between genetic variation in JAK1 (10 SNPs), JAK2 (9 SNPs), TYK2 (5 SNPs), suppressors of cytokine signaling (SOCS)1 (2 SNPs), SOCS2 (2 SNPs), STAT1 (16 SNPs), STAT2 (2 SNPs), STAT3 (6 SNPs), STAT4 (21 SNPs), STAT5A (2 SNPs), STAT5B (3 SNPs),...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22121102
DOI: 10.1002/mc.21841
PMCID: PMC3430812

Genes

TYK2
JAK2
STAT4
STAT6
STAT1
STAT3
STAT2
JAK1
SOCS1
SOCS2
IFNG
TNF

Provenance

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