Article
Signal transducer and activator of transcription 6 gene G2964A polymorphism and inflammatory bowel disease.
Clinical and experimental immunology - 1 Mar 2003
Xia B, Crusius J B A, Wu J, Zwiers A, van Bodegraven A A, Peña A S
Abstract excerpt
Signal transducer and activator of transcription 6 (STAT6) is a key transcription factor involved in interleukin 4 (IL-4) and IL-13-mediated Th2 response. The STAT6 gene is located on chromosome 12q13.3-14.1 (IBD2 region) and is therefore a positional and functional candidate gene for study in inflammatory bowel disease. We investigated the G2964A polymorphism in the 3' untranslated region of the STAT6 gene in...
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