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Article

RNAi-mediated CD40-CD154 interruption promotes tolerance in autoimmune arthritis

26 Jan 2010

Abstract excerpt

INTRODUCTION: We have previously demonstrated that ex vivo inhibition of costimulatory molecules on antigen-pulsed dendritic cells (DCs) can be useful for induction of antigen-specific immune deviation and suppression of autoimmune arthritis in the collagen induced arthritis (CIA) model. The current study evaluated a practical method of immune modulation through temporary systemic inhibition of the costimulatory...

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PMID: 20102615
DOI: 10.1186/ar2914

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