Article

Exponentially decreasing exposure of antigen generates anti-inflammatory T-cell responses

2023-09-17

Abstract excerpt

Rheumatoid Arthritis (RA) is a chronic debilitating disease characterized by auto-immune reaction towards self-antigen such as collagen type II. In this study, we investigated the impact of exponentially decreasing levels of antigen exposure on pro-inflammatory T cell responses in the collagen-induced arthritis (CIA) mouse model. Using a controlled delivery experimental approach, we manipulated the collagen type I...

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Literature Corpus work: 900e9e11-142d-5112-ac83-050e829ce47f
DOI: 10.1101/2023.09.15.558014

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