Article
Functional significance of a putative sp1 transcription factor binding site in the survivin gene promoter.
Biochemistry. Biokhimiia - 1 Nov 2008
Mityaev M V, Kopantzev E P, Buzdin A A, Vinogradova T V, Sverdlov E D
Abstract excerpt
We sequenced 1500-bp genomic DNA regions upstream from the survivin gene (BIRC5). DNA was isolated from human placenta and tumors of patients with diagnosed squamous cancer of the lung that showed high-level BIRC5 gene expression. We have revealed four new promoter allelic variants differing in single nucleotide substitutions, one variant with two nucleotide substitutions, and a variant with a TAAA...
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