Article
Survivin gene promoter -31 G/C polymorphism is associated with Wilms tumor susceptibility in Serbian children.
Journal of pediatric hematology/oncology - 1 Nov 2012
Radojevic-Skodric Sanja, Basta-Jovanovic Gordana, Brasanac Dimitrije, Nikolic Nadja, Bogdanovic Ljiljana, Milicic Biljana, Milasin Jelena
Abstract excerpt
Survivin, an apoptotic inhibitor, is overexpressed in various types of cancer. Mechanisms of survivin upregulation are still poorly understood, but single nucleotide polymorphisms in the survivin gene promoter have been shown to modulate survivin expression and consequently the risk for some types of cancer. The aim of the present study was to investigate whether survivin promoter -31 G/C and -241 C/T...
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