Article
iso-DGR sequences do not mediate binding of fibronectin N-terminal modules to adherent fibronectin-null fibroblasts.
The Journal of biological chemistry - 19 Mar 2010
Xu Jielin, Maurer Lisa M, Hoffmann Brian R, Annis Douglas S, Mosher Deane F
Abstract excerpt
Fibronectin (FN) without an RGD sequence (FN-RGE), and thus lacking the principal binding site for alpha5beta1 integrin, is deposited into the extracellular matrix of mouse embryos. Spontaneous conversion of (263)NGR and/or (501)NGR to iso-DGR possibly explains this enigma, i.e. ligation of iso-D...
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