Article
The heparin III-binding domain of fibronectin (III4-5 repeats) binds to fibronectin and inhibits fibronectin matrix assembly.
Matrix biology : journal of the International Society for Matrix Biology - 1 Oct 2007
Maqueda Alfredo, Moyano José V, Hernández Del Cerro Mercedes, Peters Donna M, Garcia-Pardo Angeles
Abstract excerpt
Fibronectin matrix assembly involves interactions among various regions of the molecule, which contribute to elongation and stabilization of the fibrils. In this study, we examined the possible role of the heparin III domain of fibronectin (repeats III4-5) in fibronectin fibrillogenesis. We show that a recombinant fragment comprising these repeats (FNIII4-5 fragment) blocked fibronectin fibril formation and the...
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