Article
Modulatory roles for integrin activation and the synergy site of fibronectin during matrix assembly.
Molecular biology of the cell - 1 Dec 1997
Sechler J L, Corbett S A, Schwarzbauer J E
Abstract excerpt
Initiation of fibronectin (FN) matrix assembly is dependent on specific interactions between FN and cell surface integrin receptors. Here, we show that de novo FN matrix assembly exhibits a slow phase during initiation of fibrillogenesis followed by a more rapid growth phase. Mn2+, which acts by enhancing integrin function, increased the rate of FN fibril growth, but only after the initial lag phase. The RGD...
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