Article
Role of type III homology repeats in cell adhesive function within the cell-binding domain of fibronectin.
The Journal of biological chemistry - 15 Feb 1991
Kimizuka F, Ohdate Y, Kawase Y, Shimojo T, Taguchi Y, Hashino K, Goto S, Hashi H, Kato I, Sekiguchi K
Abstract excerpt
Recombinant fibronectin (FN) fragments and their mutant proteins were produced to elucidate the role of type III homology repeats in cell adhesive activity within the cell-binding domain of FN. Cell adhesive activity of the 11.5-kDa fragment, the cell attachment site of the cell-binding domain, was less than 0.1% that of native FN despite the presence of the Arg-Gly-Asp-Ser sequence. The activity increased as...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.