Article
An activating mutation reveals a second binding mode of the integrin α2 I domain to the GFOGER motif in collagens.
PloS one - 1 Jan 2013
Carafoli Federico, Hamaia Samir W, Bihan Dominique, Hohenester Erhard, Farndale Richard W
Abstract excerpt
The GFOGER motif in collagens (O denotes hydroxyproline) represents a high-affinity binding site for all collagen-binding integrins. Other GxOGER motifs require integrin activation for maximal binding. The E318W mutant of the integrin α2β1 I domain displays a relaxed collagen specificity, typical of an active state. E318W binds more strongly than the wild-type α2 I domain to GMOGER, and forms a 2:1 complex with a...
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