Article
The association between a functional CYP1A1 polymorphism and colorectal neoplasia risk in post menopausal women.
Digestive diseases and sciences - 1 Oct 2010
Early Dayna S, Gao Feng, Ha Christina Y, Nagler Anne, Cole Elizabeth, Gorbe Elizabeth, Napoli Nicola, Armamento-Villareal Reina
Abstract excerpt
BACKGROUND: The impact of estrogen on risk of colorectal neoplasia is uncertain. Carriers of the AA and CA genotype allele of the C4887A polymorphism of the CYP1A1 gene have enhanced estrogen metabolism relative to carriers of the CC genotype. AIMS: This study examined whether this genetic marker of enhanced estrogen catabolism segregated with colorectal neoplasia (CRN) in postmenopausal women. METHODS: We...
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