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Article

Estrogen bioactivation, genetic polymorphisms, and ovarian cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 2005

Sellers Thomas A, Schildkraut Joellen M, Pankratz V Shane, Vierkant Robert A, Fredericksen Zachary S, Olson Janet E, Cunningham Julie, Taylor William, Liebow Mark, McPherson Carol, Hartmann Lynn C, Pal Tuya, Adjei Araba A

Abstract excerpt

Recent experimental evidence has shown that catechol estrogens can be activated through metabolism to form depurinating DNA adducts and thereby initiate cancer. Limited data are available regarding this pathway in epithelial ovarian cancer. We conducted a case-control study of 503 incident epithelial ovarian cancer cases at the Mayo Clinic in Rochester, MN, and Jacksonville, FL, and a 48-county region in North...

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PMID: 16284375
DOI: 10.1158/1055-9965.EPI-05-0142

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COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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