Article
Clinical effects of A4889G and T6235C polymorphisms in cytochrome P-450 CYP1A1 for breast cancer patients treated with tamoxifen: implications for tumor aggressiveness and patient survival.
Cancer chemotherapy and pharmacology - 1 Sept 2013
Cardoso-Filho Cassio, Sarian Luis Otavio, de Oliveira Camila Borges Martins, da Silveira Bossi Leonardo, Lourenço Gustavo Jacob, Lima Carmen Silvia Passos, Gurgel Maria Salete Costa
Abstract excerpt
PURPOSE: Individual differences in cytochrome P-450 efficiency partly explain their variations in resistance to tamoxifen and estrogen metabolism. Two polymorphisms of the CYP1A1 gene-A4889G and T6235C-are known to affect activation of estrone and estradiol and to deregulate concentration of highly active tamoxifen metabolites. However, the clinicopathologic implications of these findings have not yet been...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.