Molecular cloning and characterization of the t(2;14) translocation associated with childhood chronic lymphocytic leukemia.

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Article

Molecular cloning and characterization of the t(2;14) translocation associated with childhood chronic lymphocytic leukemia.

Oncogene - 1 May 1992

Richardson A L, Humphries C G, Tucker P W

Abstract excerpt

Two rare cases of chronic lymphocytic leukemia (CLL) in children, patients AS and LH, have been found to be associated with a unique chromosomal translocation, t(2;14)(p13;q32). Previous studies have shown the breakpoints of this translocation to be in the gamma 2 switch region of the Ig heavy-ch...

Topics

Alleles
Base Sequence
Blotting, Northern
Blotting, Southern
Cell Line
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 2
Cloning, Molecular
Humans
Immunoglobulin Heavy Chains
Immunoglobulin kappa-Chains
Leukemia, Lymphocytic, Chronic, B-Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Oligonucleotide Probes

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

RNA

Restriction Mapping

Source

Open in PubMed

Identifiers

PMID: 1373880

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1373880-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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