Article
Molecular cloning and characterization of the t(2;14) translocation associated with childhood chronic lymphocytic leukemia.
Oncogene - 1 May 1992
Richardson A L, Humphries C G, Tucker P W
Abstract excerpt
Two rare cases of chronic lymphocytic leukemia (CLL) in children, patients AS and LH, have been found to be associated with a unique chromosomal translocation, t(2;14)(p13;q32). Previous studies have shown the breakpoints of this translocation to be in the gamma 2 switch region of the Ig heavy-chain locus on chromosome 14 and in an uncharacterized region of chromosome 2. We have cloned and characterized the...
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