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Article

The BCL11 gene family: involvement of BCL11A in lymphoid malignancies

1 Dec 2001

Abstract excerpt

Many malignancies of mature B cells are characterized by chromosomal translocations involving the immunoglobulin heavy chain (IGH) locus on chromosome 14q32.3 and result in deregulated expression of the translocated oncogene. t(2;14)(p13;q32.3) is a rare event in B-cell malignancies. In contrast, gains and amplifications of the same region of chromosome 2p13 have been reported in 20% of extranodal B-cell...

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PMID: 11719382
DOI: 10.1182/blood.v98.12.3413

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