Article
MYC translocation in chronic lymphocytic leukaemia is associated with increased prolymphocytes and a poor prognosis.
British journal of haematology - 1 Jul 2008
Huh Yang O, Lin Katherine I-Chun, Vega Francisco, Schlette Ellen, Yin C Cameron, Keating Michael J, Luthra R, Medeiros L Jeffrey, Abruzzo Lynne V
Abstract excerpt
Chromosomal translocations that involve MYC, characteristic of Burkitt lymphoma, are rare in chronic lymphocytic leukaemia (CLL). We report the clinical, morphological, immunophenotypic, cytogenetic and molecular genetic features of eight CLL cases with MYC rearrangement. The patients, five men and three women (median age, 71 years) had bone marrow involvement and an absolute peripheral blood lymphocytosis; five...
Topics
- Aged
- Cell Transformation, Neoplastic
- Female
- Genes, myc
- Humans
- Immunophenotyping
- Leukemia, Lymphocytic, Chronic, B-Cell
- Lymphoid Progenitor Cells
- Male
- Middle Aged
- Mutation
- Prognosis
- Translocation, Genetic