Article
Concurrent activation of MYC and BCL2 in B cell non-Hodgkin lymphoma cell lines by translocation of both oncogenes to the same immunoglobulin heavy chain locus.
Leukemia - 1 Jul 1996
Dyer M J, Lillington D M, Bastard C, Tilly H, Lens D, Heward J M, Stranks G, Morilla R, Monrad S, Guglielmi P, Kluin-Nelemans J C, Hagemeijer A, Young B D, Catovsky D
Abstract excerpt
Concurrent activation of BCL2 and MYC usually occurs in B cell non-Hodgkin lymphoma (B-NHL) by translocation of both oncogenes to both immunoglobulin heavy chain (IGH) alleles: this abrogates immunoglobulin synthesis. We have studied three B-NHL cell lines (DoHH2, VAL and ROS 50) and show that concurrent activation of BCL2 and MYC may follow translocation of both oncogenes to the same IGH allele. Conventional...
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