Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The configuration of the immunoglobulin genes in B cell chronic lymphocytic leukemia.

Leukemia - 1 Jun 2002

Dyer M J S, Oscier D G

Abstract excerpt

B cell chronic lymphocytic leukemia (CLL) lacks a consistent genetic abnormality. However, immunoglobulin V(H) gene segment mutation analysis has provided insights into the pathogenesis of these diseases and allowed the development of powerful prognostic markers. Immunoglobulin gene chromosomal translocations are rare in CLL and involve a distinct subset of genes including BCL3, BCL11A and CCND2. BCL2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Rearrangement, B-Lymphocyte
Share to Genes, Immunoglobulin
Share to Immunoglobulin Heavy Chains

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoglobulin Variable Region

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Sequence Alignment

Share to Somatic Hypermutation, Immunoglobulin

Share to Translocation, Genetic

Source

Identifiers

PMID: 12040429
DOI: 10.1038/sj.leu.2402528

Genes

BCL11A
BCL2
BCL3
CCND2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The configuration of the immunoglobulin genes in B cell chronic lymphocytic leukemia.PMID 12040429Read ↗

Immunoglobulin genes in chronic lymphocytic leukemia: key to understanding the disease and improving risk stratificationSemantic proximity Read ↗

The immunoglobulin genes: structure and specificity in chronic lymphocytic leukemia.Semantic proximity Read ↗

Immunoglobulin gene rearrangements and mutational status in argentinian patients with chronic lymphocytic leukemia.Semantic proximity Read ↗

Oncogene rearrangements in chronic B-cell leukemia.Semantic proximity Read ↗

Role of the B-cell receptor in chronic lymphocytic leukemia: where do we stand?Semantic proximity Read ↗

Differential rates of somatic hypermutation in V(H) genes among subsets of chronic lymphocytic leukemia defined by chromosomal abnormalities.Semantic proximity Read ↗

BCL2 translocations in leukemias of mature B cellsSemantic proximity Read ↗

Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins.Semantic proximity Read ↗

Preferential linkage of bcl-2 to immunoglobulin light chain gene in chronic lymphocytic leukemia.Semantic proximity Read ↗

Comprehensive characterization of immunoglobulin gene rearrangements in patients with chronic lymphocytic leukaemia.Semantic proximity Read ↗

Similarities and differences between the light and heavy chain Ig variable region gene repertoires in chronic lymphocytic leukemia.Semantic proximity Read ↗

Evidence of biased immunoglobulin variable gene usage in highly stable B-cell chronic lymphocytic leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.