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Article

Increased levels of DNA methyltransferases are associated with the tumorigenic capacity of prostate cancer cells.

Oncology reports - 1 Mar 2013

Gravina Giovanni Luca, Ranieri Guido, Muzi Paola, Marampon Francesco, Mancini Andrea, Di Pasquale Boris, Di Clemente Luigi, Dolo Vincenza, D'Alessandro Anna Maria, Festuccia Claudio

Abstract excerpt

DNA methylation might be the earliest somatic genome changes in prostate cancer that also play an important role in the process of tumor invasion, growth and metastasis. In recent years, several inhibitors of DNA methyltransferases (DNMTis) have been developed and evaluated in pre-clinical models and in clinical trials. While these compounds are effective in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23254386
DOI: 10.3892/or.2012.2192

Genes

DNMT1
GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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