Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prolyl hydroxylase EGLN3 regulates skeletal myoblast differentiation through an NF-kappaB-dependent pathway.

The Journal of biological chemistry - 19 Mar 2010

Fu Jian, Taubman Mark B

Abstract excerpt

The egg-laying abnormal-9 (EGLN) prolyl hydroxylases have been shown to regulate the stability and thereby the activity of the alpha subunits of hypoxia-inducible factor (HIF) through its ability to catalyze their hydroxylation. We have previously shown that EGLN3 promotes differentiation of C2C1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression Regulation, Enzymologic
Share to Genes, Dominant
Share to Hypoxia-Inducible Factor 1, alpha Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myoblasts, Skeletal

Share to NF-kappa B

Share to Procollagen-Proline Dioxygenase

Share to RNA Interference

Share to RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 20089853
DOI: 10.1074/jbc.M109.078600
PMCID: PMC2838314

Genes

EGLN3
TRAF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20089853-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prolyl hydroxylase EGLN3 regulates skeletal myoblast differentiation through an NF-kappaB-dependent pathway.PMID 20089853Read ↗

Increase in HDAC9 suppresses myoblast differentiation via epigenetic regulation of autophagy in hypoxiaSemantic proximity Read ↗

Regulation of HDAC9 gene expression by MEF2 establishes a negative-feedback loop in the transcriptional circuitry of muscle differentiation.Semantic proximity Read ↗

4-Phenylbutyric Acid Activates an NF-κB - Egr-1 Axis to Control Myoblast Proliferation and ECM Gene Expression ProfilesSemantic proximity Read ↗

Prolyl hydroxylase domain 2 deficiency promotes skeletal muscle fiber-type transition via a calcineurin/NFATc1-dependent pathway.Semantic proximity Read ↗

Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1α oxygen-dependent degradation domainSemantic proximity Read ↗

Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure.Semantic proximity Read ↗

Zinc transporter ZIP13 is involved in myogenic differentiation: establishment of Ehlers– Danlos syndrome spondylodysplastic type 3 induced pluripotent stem cellsSemantic proximity Read ↗

Estrogen receptor β sustains epithelial differentiation by regulating prolyl hydroxylase 2 transcription.Semantic proximity Read ↗

Inhibition of aberrant Hif1α activation delays intervertebral disc degeneration in adult miceSemantic proximity Read ↗

Promotion of chondrocyte-specific function by inhibition of HIF-targeting hydroxylasesSemantic proximity Read ↗

HIF modulation of Wnt signaling regulates skeletal myogenesis in vivo.Semantic proximity Read ↗

Two distinct roles for EGL-9 in the regulation of HIF-1-mediated gene expression in Caenorhabditis elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.