Article
The impact of genetic background on mouse models of kidney disease.
Kidney international - 1 Jul 2022
Bufi Rei, Korstanje Ron
Abstract excerpt
The mouse is the most commonly used mammalian model to study disease, including kidney disease. However, close attention needs to be paid to the differences and effects of genetic background. The default choice of most investigators is to use C57BL/6 mice, but not all C57BL/6 mice are the same. Ever since the C57BL/6 line was first established, differences in the genetic background have risen between substrains,...
Topics
Join the communities discussing this publication.