Modulation of immune responses in lentiviral vector-mediated gene transfer

Abstract excerpt

• Immune responses may be detrimental to both the safety and efficacy of gene therapy. • Design and manufacturing can be tuned to reduce vector immunogenicity. • Active transgene-specific immune tolerance is desirable in gene therapy. • Novel targeted immune-modulatory strategies can be explored to improve gene therapy. Lentiviral vectors (LV) are widely used vehicles for gene transfer and therapy in pre-clinical...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to CAR-T cell therapy research
• Share to Viral Infectious Diseases and Gene Expression in Insects
• Share to Virus-based gene therapy research