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The Era of Gene Therapy: The Advancement of Lentiviral Vectors and Their Pseudotyping

24 Jul 2025

Abstract excerpt

Over 35 years of history, the field of gene therapy has undergone much progress. The initial concept-the replacement of dysfunctional genes with correct ones-has advanced to the next stage and reached the level of precise genome editing. Dozens of gene therapy products based on viral and non-viral delivery platforms have been approved, marking the dawn of the gene therapy era. These viral vector strategies rely...

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PMID: 40872751
DOI: 10.3390/v17081036

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