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Article

KLF15 Loss-of-Function Mutation Underlying Atrial Fibrillation as well as Ventricular Arrhythmias and Cardiomyopathy.

Genes - 12 Mar 2021

Li Ning, Xu Ying-Jia, Shi Hong-Yu, Yang Chen-Xi, Guo Yu-Han, Li Ruo-Gu, Qiu Xing-Biao, Yang Yi-Qing, Zhang Min

Abstract excerpt

Atrial fibrillation (AF) represents the most common type of clinical cardiac arrhythmia and substantially increases the risks of cerebral stroke, heart failure and death. Accumulating evidence has convincingly demonstrated the strong genetic basis of AF, and an increasing number of pathogenic variations in over 50 genes have been causally linked to AF. Nevertheless, AF is of pronounced genetic heterogeneity, and...

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Identifiers

PMID: 33809104
DOI: 10.3390/genes12030408
PMCID: PMC8001991

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