Article
Podocyte injury induces nuclear translocation of WTIP via microtubule-dependent transport.
The Journal of biological chemistry - 26 Mar 2010
Kim Jane H, Konieczkowski Martha, Mukherjee Amitava, Schechtman Sam, Khan Shenaz, Schelling Jeffrey R, Ross Michael D, Bruggeman Leslie A, Sedor John R
Abstract excerpt
Podocyte structural and transcriptional phenotype plasticity characterizes glomerular injury. Transcriptional activity of WT1 (Wilm's tumor 1) is required for normal podocyte structure and is repressed by the podocyte adherens junction protein, WTIP (WT1 interacting protein). Here we show that WT...
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