Article
Multi-platform whole-genome microarray analyses refine the epigenetic signature of breast cancer metastasis with gene expression and copy number.
PloS one - 13 Jan 2010
Andrews Joseph, Kennette Wendy, Pilon Jenna, Hodgson Alexandra, Tuck Alan B, Chambers Ann F, Rodenhiser David I
Abstract excerpt
BACKGROUND: We have previously identified genome-wide DNA methylation changes in a cell line model of breast cancer metastasis. These complex epigenetic changes that we observed, along with concurrent karyotype analyses, have led us to hypothesize that complex genomic alterations in cancer cells...
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