Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens

13 Jan 2014

Abstract excerpt

Apoptotic cells are a source of autoantigens and impairment of their removal contributes to the development of autoimmunity in C1q deficiency. However, the lack of complement component 3 (C3), the predominant complement opsonin, does not predispose to autoimmunity, suggesting a modifying role of C3 in disease pathogenesis. To explore this hypothesis, here we investigated the role of C3 in the T-cell response to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complement system in diseases
Share to Phagocytosis and Immune Regulation
Share to SARS-CoV-2 and COVID-19 Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24474777
DOI: 10.1073/pnas.1316877111

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigensPMID 24474777Read ↗

The clearance of dying cells: table for twoSemantic proximity Read ↗

Links between complement deficiency and apoptosis.Semantic proximity Read ↗

Contribution of Defective PS Recognition and Efferocytosis to Chronic Inflammation and AutoimmunitySemantic proximity Read ↗

A Hierarchical Role for Classical Pathway Complement Proteins in the Clearance of Apoptotic Cells in VivoSemantic proximity Read ↗

T cell/transmembrane, Ig, and mucin-3 allelic variants differentially recognize phosphatidylserine and mediate phagocytosis of apoptotic cells.Semantic proximity Read ↗

The endothelial deprotection hypothesis for lupus pathogenesis: the dual role of C1q as a mediator of clearance and regulator of endothelial permeabilitySemantic proximity Read ↗

Efficient T cell activation via a Toll-Interleukin 1 Receptor-independent pathway.Semantic proximity Read ↗

The clearance of apoptotic cells by complement.Semantic proximity Read ↗

Dendritic cell synthesis of C3 is required for full T cell activation and development of a Th1 phenotype.Semantic proximity Read ↗

Antigen delivery to early endosomes eliminates the superiority of human blood BDCA3+ dendritic cells at cross presentation.Semantic proximity Read ↗

C1q, Autoimmunity and ApoptosisSemantic proximity Read ↗

[Role of the complement C3 protein in the control of the specific immune response].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.