Article
Multifactor dimensionality reduction for graphics processing units enables genome-wide testing of epistasis in sporadic ALS.
Bioinformatics (Oxford, England) - 1 Mar 2010
Greene Casey S, Sinnott-Armstrong Nicholas A, Himmelstein Daniel S, Park Paul J, Moore Jason H, Harris Brent T
Abstract excerpt
MOTIVATION: Epistasis, the presence of gene-gene interactions, has been hypothesized to be at the root of many common human diseases, but current genome-wide association studies largely ignore its role. Multifactor dimensionality reduction (MDR) is a powerful model-free method for detecting epist...
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