Article
GLIDE: GPU-based linear regression for detection of epistasis.
Human heredity - 1 Jan 2012
Kam-Thong Tony, Azencott Chloé-Agathe, Cayton Lawrence, Pütz Benno, Altmann André, Karbalai Nazanin, Sämann Philipp G, Schölkopf Bernhard, Müller-Myhsok Bertram, Borgwardt Karsten M
Abstract excerpt
Due to recent advances in genotyping technologies, mapping phenotypes to single loci in the genome has become a standard technique in statistical genetics. However, one-locus mapping fails to explain much of the phenotypic variance in complex traits. Here, we present GLIDE, which maps phenotypes to pairs of genetic loci and systematically searches for the epistatic interactions expected to reveal part of this...
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