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Article

Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells.

Nature communications - 13 Sept 2018

Lager Angela M, Corradin Olivia G, Cregg Jared M, Elitt Matthew S, Shick H Elizabeth, Clayton Benjamin L L, Allan Kevin C, Olsen Hannah E, Madhavan Mayur, Tesar Paul J

Abstract excerpt

Oligodendrocyte dysfunction underlies many neurological disorders, but rapid assessment of mutation-specific effects in these cells has been impractical. To enable functional genetics in oligodendrocytes, here we report a highly efficient method for generating oligodendrocytes and their progenitors from mouse embryonic and induced pluripotent stem cells, independent of mouse strain or mutational status. We...

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Identifiers

PMID: 30213958
DOI: 10.1038/s41467-018-06102-7
PMCID: PMC6137209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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