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Article

MYCN-regulated microRNAs repress estrogen receptor-α ( <i>ESR1</i> ) expression and neuronal differentiation in human neuroblastoma

4 Jan 2010

Abstract excerpt

MYCN, a proto-oncogene normally expressed in the migrating neural crest, is in its amplified state a key factor in the genesis of human neuroblastoma (NB). However, the mechanisms underlying MYCN-mediated NB progression are poorly understood. Here, we present a MYCN-induced miRNA signature in human NB involving the activation and transrepression of several miRNA genes from paralogous clusters. Several family...

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PMID: 20080637
DOI: 10.1073/pnas.0913517107

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