Back to search

Article

HIF2α negatively regulates MYCN protein levels and promotes a low-risk noradrenergic phenotype in neuroblastoma

2024-11-21

Abstract excerpt

The role of HIF2α, encoded by EPAS1 , in neuroblastoma remains controversial. Here we demonstrate that induction of high levels of HIF2α in MYCN-amplified neuroblastoma cells results in a rapid and profound reduction of the oncoprotein MYCN. This is followed by an upregulation of genes characteristic of noradrenergic cells in the adrenal medulla. Additionally, upon induction of HIF2α, the proliferation rate drops...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
0d318345-f7a0-5c83-ae96-a20d7e99a475
DOI
10.1101/2024.11.20.624001
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
HIF2α negatively regulates MYCN protein levels and promotes a low-risk noradrenergic phenotype in neuroblastomaDOI 10.1101/2024.11.20.624001
HIF-2α maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cellsSemantic proximity
Combinatorial Regulation of Neuroblastoma Tumor Progression by N-Myc and Hypoxia Inducible Factor HIF-1αSemantic proximity
HIF2A and IGF2 Expression Correlates in Human Neuroblastoma Cells and Normal Immature Sympathetic NeuroblastsSemantic proximity
Hypoxia and hypoxia-inducible factors in neuroblastomaSemantic proximity
High Myc pathway activity and low stage of neuronal differentiation associate with poor outcome in neuroblastomaSemantic proximity
MYCN in Neuroblastoma: “Old Wine into New Wineskins”Semantic proximity
MYCN-amplified neuroblastoma maintains an aggressive and undifferentiated phenotype by deregulation of estrogen and NGF signaling.Semantic proximity
The HIF-2α-driven pseudo-hypoxic phenotype in tumor aggressiveness, differentiation, and vascularization.Semantic proximity
Role of hypoxia and HIF2α in development of the sympathoadrenal cell lineage and chromaffin cell tumors with distinct catecholamine phenotypic features.Semantic proximity
ARNT-dependent HIF-2 transcriptional activity is not sufficient to regulate downstream target genes in neuroblastomaSemantic proximity
Differential regulation of HIF-1α and HIF-2α in neuroblastoma: Estrogen-related receptor alpha (ERRα) regulates HIF2A transcription and correlates to poor outcomeSemantic proximity
Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastomaSemantic proximity
Select a neighboring publication to make it the new centre.