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Article

Optimization of DNA polymerase mutation rates during bacterial evolution.

Proceedings of the National Academy of Sciences of the United States of America - 19 Jan 2010

Loh Ern, Salk Jesse J, Loeb Lawrence A

Abstract excerpt

Mutation rate is an important determinant of evolvability. The optimal mutation rate for different organisms during evolution has been modeled in silico and tested in vivo, predominantly through pairwise comparisons. To characterize the fitness landscape across a broad range of mutation rates, we generated a panel of 66 DNA polymerase I mutants in Escherichia coli with comparable growth properties, yet with...

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Identifiers

PMID: 20080608
DOI: 10.1073/pnas.0912451107
PMCID: PMC2824296

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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