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Article

Dynamics of adaptive microevolution of hypermutable Pseudomonas aeruginosa during chronic pulmonary infection in patients with cystic fibrosis.

The Journal of infectious diseases - 1 Jul 2009

Hoboth Christina, Hoffmann Reinhard, Eichner Anja, Henke Christine, Schmoldt Sabine, Imhof Axel, Heesemann Jürgen, Hogardt Michael

Abstract excerpt

BACKGROUND: In patients with cystic fibrosis (CF), the emergence of hypermutable Pseudomonas aeruginosa drives the selection of P. aeruginosa variants that are efficiently adapted to the inflamed lungs of these patients. OBJECTIVE: To provide a detailed survey of adaptive changes in the physiolog...

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Identifiers

PMID: 19459782
DOI: 10.1086/599360

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19459782-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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