Article
Association of the methylenetetrahydrofolate reductase polymorphism in Korean patients with childhood acute lymphoblastic leukemia.
Anticancer research - 1 Jan 2000
Kim Nam Keun, Chong So Young, Jang Moon Ju, Hong Seung Ho, Kim Heung Sik, Cho Eun Kyung, Lee Jung Ae, Ahn Myung Ju, Kim Chul Soo, Oh Doyeun
Abstract excerpt
BACKGROUND: Methylenetetrahydrofolate reductase plays a central role in converting folate to methyl donor for DNA methylation. Recently, methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) mutations were discovered to be associated with childhood acute lymphoblastic leukemia (ALL), as we...
Topics
- Adolescent
- Child
- Child, Preschool
- DNA, Neoplasm
- Female
- Genotype
- Humans
- Infant
- Korea
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Mutation
- Polymorphism, Genetic
- Precursor Cell Lymphoblastic Leukemia-Lymphoma