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Article

Brain Anatomical Mediators of GRIN2B Gene Association with Attention/Hyperactivity Problems: An Integrated Genetic-Neuroimaging Study.

Genes - 30 Jul 2021

Nobile Maria, Maggioni Eleonora, Mauri Maddalena, Garzitto Marco, Piccin Sara, Bonivento Carolina, Giorda Roberto, Girometti Rossano, Tomasino Barbara, Molteni Massimo, Fabbro Franco, Brambilla Paolo

Abstract excerpt

This study aims to investigate the genetic and neural determinants of attention and hyperactivity problems. Using a proof-of-concept imaging genetics mediation design, we explore the relationship between the glutamatergic GRIN2B gene variants and inattention/hyperactivity with neuroanatomical measures as intermediates. Fifty-eight children and adolescents were evaluated for behavioral problems at three time...

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PMID: 34440367
DOI: 10.3390/genes12081193
PMCID: PMC8394308

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