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Article

Generation and characterization of CD1d‐specific single‐domain antibodies with distinct functional features

17 Jun 2016

Abstract excerpt

Ligation of the CD1d antigen-presenting molecule by monoclonal antibodies (mAbs) can trigger important biological functions. For therapeutic purposes camelid-derived variable domain of heavy-chain-only antibodies (VHH) have multiple advantages over mAbs because they are small, stable and have low immunogenicity. Here, we generated 21 human CD1d-specific VHH by immunizing Lama glama and subsequent phage display....

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Identifiers

PMID: 27312006
DOI: 10.1111/imm.12635

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