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Article

Carriers of loss-of-function mutations in ABCA1 display pancreatic beta-cell dysfunction.

Diabetes care - 1 Apr 2010

Vergeer Menno, Brunham Liam R, Koetsveld Joris, Kruit Janine K, Verchere C Bruce, Kastelein John J P, Hayden Michael R, Stroes Erik S G

Abstract excerpt

OBJECTIVE: Abnormal cellular cholesterol handling in islets may contribute to beta-cell dysfunction in type 2 diabetes. beta-Cell deficiency for the ATP binding cassette transporter A1 (ABCA1), which mediates the efflux of cellular cholesterol, leads to altered intracellular cholesterol homeostas...

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Source

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Identifiers

PMID: 20067955
DOI: 10.2337/dc09-1562
PMCID: PMC2845043

Genes

ABCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20067955-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Carriers of loss-of-function mutations in ABCA1 display pancreatic beta-cell dysfunction.PMID 20067955Read ↗

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