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Article

The ATP-binding cassette transporter subfamily A member 1 (ABC-A1) and type 2 diabetes: an association beyond HDL cholesterol.

Current diabetes reviews - 1 Nov 2007

Salinas Carlos A Aguilar, Cruz-Bautista Ivette, Mehta Roopa, Villarreal-Molina Ma T, Pérez Francisco J G, Tusié-Luna Ma T, Canizales-Quinteros Samuel

Abstract excerpt

Recent findings from several groups demonstrate that ABC-A1 participates in the pathogenesis of the metabolic syndrome and type 2 diabetes. A variant of the ABC-A1 gene (R230C) is associated with the metabolic syndrome and its co-morbidities in Mexicans. Its presence is associated with an increased risk for obesity, the metabolic syndrome and type 2 diabetes. R230C is found exclusively in Amerindian and...

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Share to Amino Acid Substitution
Share to Apolipoprotein A-I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter 1

Share to ATP-Binding Cassette Transporters

Share to Cholesterol, HDL

Share to Diabetes Mellitus, Type 2

Share to Genetic Variation

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 18220685
DOI: 10.2174/157339907782329979

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

The ATP-binding cassette transporter subfamily A member 1 (ABC-A1) and type 2 diabetes: an association beyond HDL cholesterol.PMID 18220685Read ↗

The Role of the ATP-Binding Cassette A1 (ABCA1) in Human Disease.Semantic proximity Read ↗

R230C but not - 565C/T variant of the ABCA1 gene is associated with type 2 diabetes in Mexicans through an effect on lowering HDL-cholesterol levels.Semantic proximity Read ↗

Association of the ATP-binding cassette transporter A1 R230C variant with early-onset type 2 diabetes in a Mexican population.Semantic proximity Read ↗

The ATP-Binding Cassette Transporter A1 R230C Variant Affects HDL Cholesterol Levels and BMI in the Mexican PopulationSemantic proximity Read ↗

The non-synonymous Arg230Cys variant (R230C) of the ATP-binding cassette transporter A1 is associated with low HDL cholesterol concentrations in Mexican adults: a population based nation wide study.Semantic proximity Read ↗

Variations on a gene: rare and common variants in ABCA1 and their impact on HDL cholesterol levels and atherosclerosis.Semantic proximity Read ↗

A functional ABCA1 gene variant is associated with low HDL-cholesterol levels and shows evidence of positive selection in Native Americans.Semantic proximity Read ↗

Novel association of the R230C variant of the ABCA1 gene with high triglyceride levels and low high-density lipoprotein cholesterol levels in Mexican school-age children with high prevalence of obesity.Semantic proximity Read ↗

ABCA1, ApoA-I and type II DM.Semantic proximity Read ↗

Association of HDL deficiency with a novel mutation in the ABCA1 gene.Semantic proximity Read ↗

The ABCA1 gene R230C variant is associated with decreased risk of premature coronary artery disease: the genetics of atherosclerotic disease (GEA) study.Semantic proximity Read ↗

ABCA1 Variants rs1800977 (C69T) and rs9282541 (R230C) Are Associated with Susceptibility to Type 2 Diabetes.Semantic proximity Read ↗

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