Article
ABC transporter genes and risk of type 2 diabetes: a study of 40,000 individuals from the general population.
Diabetes care - 1 Dec 2012
Schou Jesper, Tybjærg-Hansen Anne, Møller Holger J, Nordestgaard Børge G, Frikke-Schmidt Ruth
Abstract excerpt
OBJECTIVE: Alterations of pancreatic β-cell cholesterol content may contribute to β-cell dysfunction. Two important determinants of intracellular cholesterol content are the ATP-binding cassette (ABC) transporters A1 (ABCA1) and -G1 (ABCG1). Whether genetic variation in ABCA1 and ABCG1 predicts risk of type 2 diabetes in the general population is unknown. RESEARCH DESIGN AND METHODS: We tested whether genetic...
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