Article
Association of the ATP-binding cassette transporter A1 R230C variant with early-onset type 2 diabetes in a Mexican population.
Diabetes - 1 Feb 2008
Villarreal-Molina M Teresa, Flores-Dorantes M Teresa, Arellano-Campos Olimpia, Villalobos-Comparan Marisela, Rodríguez-Cruz Maricela, Miliar-García Angel, Huertas-Vazquez Adriana, Menjivar Marta, Romero-Hidalgo Sandra, Wacher Niels H, Tusie-Luna M Teresa, Cruz Miguel, Aguilar-Salinas Carlos A, Canizales-Quinteros Samuel
Abstract excerpt
OBJECTIVE: The ATP-binding cassette transporter A1 (ABCA1) R230C variant is associated with low HDL cholesterol levels, obesity, and the metabolic syndrome in Mexican-Mestizos. Because a pivotal role for ABCA1 in pancreatic beta-cell function was recently observed in the mouse model, we assessed the association of this variant with type 2 diabetes in this population. RESEARCH DESIGN AND METHODS: The initial group...
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