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Article

Loss-of-function mutations in ABCA1 and enhanced β-cell secretory capacity in young adults.

Diabetes - 1 Jan 2015

Rickels Michael R, Goeser Eugen S, Fuller Carissa, Lord Christine, Bowler Anne M, Doliba Nicolai M, Hegele Robert A, Cuchel Marina

Abstract excerpt

Loss-of-function mutations affecting the cholesterol transporter ATP-binding cassette transporter subfamily A member 1 (ABCA1) impair cellular cholesterol efflux and are associated with reduced HDL-cholesterol (HDL-C) levels. ABCA1 may also be important in regulating β-cell cholesterol homeostasis and insulin secretion. We sought to determine whether loss-of-function ABCA1 mutations affect β-cell secretory...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 25125487
DOI: 10.2337/db14-0436
PMCID: PMC4274805

Genes

ABCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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